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1

Brain distribution of idebenone and its effect on local cerebral glucose utilization in rats

Yasuo Nagai, Kiyoshi Yoshida, Shigehiko Narumi, Shigeharu Tanayama, Akinobu Nagaoka

Journal:

Archives of Gerontology and Geriatrics

Year:

1989

Language:

english

File:

PDF, 2.37 MB

english, 1989

2

Characterization of Conjugated Metabolites of a New Angiotensin II Receptor Antagonist, Candesartan Cilexetil, in Rats by Liquid Chromatography/Electrospray Tandem Mass Spectrometry Following Chemical Derivatization

Kondo, Takahiro, Yoshida, Kiyoshi, Yoshimura, Yoshinobu, Motohashi, Michio, Tanayama, Shigeharu

Journal:

Journal of Mass Spectrometry

Year:

1996

Language:

english

File:

PDF, 500 KB

english, 1996

3

Possible factor for nonlinear pharmacokinetics of TAK-603, a new antirheumatic agent, in rats

Yoshihiko Tagawa, Kiyoshi Miwa, Kenji Yamashita, Ryoichi Tsukuda, Yoshinobu Yoshimura, Shigeharu Tanayama, Yusuke Tanigawara

Journal:

Biopharmaceutics & Drug Disposition

Year:

1999

Language:

english

File:

PDF, 158 KB

english, 1999

4

Enantioselective pharmacokinetics in animals of pazinaclone, a new isoindoline anxiolytic, and its active metabolite

Takahiro Kondo, Kiyoshi Yoshida, Yoshinobu Yoshimura, Shigeharu Tanayama

Journal:

Biopharmaceutics & Drug Disposition

Year:

1995

Language:

english

File:

PDF, 838 KB

english, 1995

5

Analysis of dog and rat plasma for metabolites of a new isoindoline anxiolytic, DN-2327, by liquid chromatography/thermospray mass spectrometry and tandem mass spectrometry

Takahiro Kondo, Kiyoshi Yoshida, Shigeharu Tanayama

Journal:

Biological Mass Spectrometry = Journal of Mass Spectrometry (Wiley)

Year:

1994

Language:

english

File:

PDF, 534 KB

english, 1994

6

Enantioselective determination of pazinaclone, a new isoindoline anxiolytic, and its active metabolite in rat plasma by high-performance liquid chromatography

Takahiro Kondo, Kenji Hamasaki, Masashi Yamaguchi, Isamu Aoki, Kiyoshi Yoshida, Yoshinobu Yoshimura, Shigeharu Tanayama

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1995

Language:

english

File:

PDF, 420 KB

english, 1995

7

Simple and rapid ion-pair high-performance liquid chromatographic assay for p-nitrophenyl glucuronide in rat-liver microsomal incubations

Michio Motohashi, Motohashi Torii, Takayoshi Doi, Shigeharu Tanayama

Journal:

Journal of Chromatography A

Year:

1982

Language:

english

File:

PDF, 261 KB

english, 1982

8

Delapril

Yoshikazu Oka, Kohei Nishikawa, Go Kito, Hiroshi Mayahara, Shigeharu Tanayama, Hiroshi Muto, Kentaro Hiraga

Journal:

Cardiovascular Therapeutics

Year:

1988

Language:

english

File:

PDF, 878 KB

english, 1988

9

Metabolism of 8-Chloro-6-phenyl-4 H-s -triazolo[4,3- a ]-[1,4]benzodiazepine (D-40TA), a New Central Depressant. IV. Placental Transfer and Excretion in Milk in Rats

Tanayama, Shigeharu, Momose, Sachiko, Kanai, Yoshio, Shirakawa, Yoshihiro

Journal:

Year:

1974

Language:

english

File:

PDF, 553 KB

english, 1974

10

Comparative Studies on the Metabolic Disposition of 8-Chloro-6-pheny1–4 H-s -triazolo[4,3- a ][1,4]benzo-diazepine (D-40TA) and Nitrazepam after Single and Repeated Administration in Rats

Tanayama, Shigeharu, Momose, Sachiko, Kanai, Yoshio

Journal:

Year:

1974

Language:

english

File:

PDF, 483 KB

english, 1974

11

Metabolism of 6-Chloro-5-cyclohexylindane-1-carboxylic Acid (TAI-284), a New Non-steroidal Anti-inflammatory Agent. II. Isolation and Identification of Metabolites in the Perfusate of the Isolated Liver Perfusion in Rats

Kanai, Yoshio, Kobayashi, Takuo, Tanayama, Shigeharu

Journal:

Year:

1973

Language:

english

File:

PDF, 967 KB

english, 1973

12

Biotransformation of 3-(2′,4′,5′-Triethoxybenzoyl)propionic Acid, a New Biliary Smooth Muscle Relaxant with Choleretic Activity, in Rats

Kobayashi, Takuo, Tanayama, Shigeharu, Kanai, Yoshio

Journal:

Year:

1978

Language:

english

File:

PDF, 877 KB

english, 1978

13

Metabolism of 6-Chloro-5-cyclohexylindane-1-carboxylic Acid (TAI-284), a New Non-steroidal Anti-inflammatory Agent. III. Species Differences in Metabolism

Tanayama, Shigeharu

Journal:

Year:

1973

Language:

english

File:

PDF, 669 KB

english, 1973

14

Metabolism of 6-Chloro-5-cyclohexylindane-1-carboxylic Acid (TAI-284), a New Non-steroidal Anti-inflammatory Agent. I. Absorption, Distribution and Excretion in Rats

Tanayama, Shigeharu, Tsuchida, Eiko, Suzuoki, Ziro

Journal:

Year:

1973

Language:

english

File:

PDF, 903 KB

english, 1973

15

Metabolic Disposition of 6-Ethyl-3-(1 H -tetrazol-5-yl)-chromone, a New Antiallergic Agent, in the Rat, Guinea-pig, Rabbit, Dog and Monkey

Kanai, Yoshio, Nakai, Yoichi, Nakajima, Nobuyuki, Tanayama, Shigeharu

Journal:

Year:

1979

Language:

english

File:

PDF, 1.14 MB

english, 1979

16

Metabolic Disposition of 6-Chloro-5-cyclohexyl-1-indancarboxylic Acid (TAI-284), a New Non-steroidal Anti-inflammatory Agent, in Rhesus Monkeys

Tanayama, Shigeharu, Kanai, Yoshio

Journal:

Year:

1977

Language:

english

File:

PDF, 630 KB

english, 1977

17

Biotransformation of Molsidomine ( N -Ethoxycarbonyl-3-morpholinosydnonimine), a New Anti-anginal Agent, in Rats

Tanayama, Shigeharu, Nakai, Yoichi, Fujita, Takeshi, Suzuoki, Ziro, Imashiro, Yoshio, Masuda, Katsutada

Journal:

Year:

1974

Language:

english

File:

PDF, 1.02 MB

english, 1974

18

Decrease in the Concentrations of Ketone Bodies and Free Fatty Acids in Rat Blood in Response to a Glucose Load: Its Possible Relation to Endogenous Insulin Activity

TANAYAMA, SHIGEHARU, UI, MICHIO

Journal:

Year:

1965

Language:

english

File:

PDF, 529 KB

english, 1965

19

Metabolism of 3-(2′,4′,5′-Triethoxybenzoyl)propionic Acid, a New Biliary Smooth Muscle Relaxant with Choleretic Activity: II. Metabolism after Repeated Dosing in Rats, in Relation to Choleretic Activity

Tanayama, Shigeharu, Kobayashi, Takuo, Kanai, Yoshio

Journal:

Year:

1978

Language:

english

File:

PDF, 571 KB

english, 1978

20

Metabolism of 3-(2′,4′,5′-Triethoxybenzoyl)propionic Acid, a New Biliary Smooth Muscle Relaxant with Choleretic Activity: I. Disposition after a Single Administration in Rats and Dogs

Tanayama, Shigeharu, Kobayashi, Takuo, Kanai, Yoshio

Journal:

Year:

1978

Language:

english

File:

PDF, 1.05 MB

english, 1978

21

Metabolism of 8-Chloro-6-phenyl-4 H -s-triazolo[4,3-α][1,4]-benzodiazepine (D–40TA), a New Central Depressant. I. Absorption, Distribution and Excretion in Rats

Tanayama, Shigeharu, Shirakawa, Yoshihiro, Kanai, Yoshio, Suzuoki, Ziro

Journal:

Year:

1974

Language:

english

File:

PDF, 468 KB

english, 1974

22

Metabolism of 6-Chloro-5-cyclohexylindan-1-carboxylic Acid (TAI-284), a New Non-steroidal Anti-inflammatory Agent, in Relation to Ulcerogenic Activity

Tanayama, Shigeharu

Journal:

Year:

1974

Language:

english

File:

PDF, 705 KB

english, 1974

23

Human Urinary Metabolites of 3-(2′,4′,5′-Triethoxybenzoyl)propionic Acid, a New Biliary Smooth Muscle Relaxant with Choleretic Activity

Kobayashi, Takuo, Kanai, Yoshio, Tanayama, Shigeharu

Journal:

Year:

1978

Language:

english

File:

PDF, 572 KB

english, 1978

24

Metabolism of 8-Chloro-6-phenyl-4 H -s-triazolo[4,3-α][1,4]-benzodiazepine (D–40TA), a New Central Depressant. II. Species Difference in Metabolism

Tanayama, Shigeharu, Kanai, Yoshio

Journal:

Year:

1974

Language:

english

File:

PDF, 318 KB

english, 1974

25

Metabolism of 8-Chloro-6-phenyl-4 H -s-triazolo[4,3-α][1,4]-benzodiazepine (D–40TA), a New Central Depressant. III. Metabolism and Tolerance Studies in Rats

Tanayama, Shigeharu, Momose, Sachiko, Takagaki, Etsuko

Journal:

Year:

1974

Language:

english

File:

PDF, 348 KB

english, 1974

26

Disposition of idebenone (CV-2619), a new cerebral metabolism improving agent, in rats and dogs.

TORII, HIROSHI, YOSHIDA, KIYOSHI, KOBAYASHI, TAKUO, TSUKAMOTO, TAKEJI, TANAYAMA, SHIGEHARU

Journal:

Journal of Pharmacobio-Dynamics

Year:

1985

File:

PDF, 1.04 MB

1985

27

Metabolism of idebenone (CV-2619), a new cerebral metabolism improving agent: Isolation and identification of metabolites in the rat and dog.

KOBAYASHI, TAKUO, YOSHIDA, KIYOSHI, MITANI, MASAYOSHI, TORII, HIROSHI, TANAYAMA, SHIGEHARU

Journal:

Journal of Pharmacobio-Dynamics

Year:

1985

File:

PDF, 860 KB

1985

28

ENDURACIDIN, A NEW ANTIBIOTIC. IV

TANAYAMA, SHIGEHARU, FUGONO, TAKESHI, YAMAZAKI, TOSHIYUKI

Journal:

The Journal of Antibiotics

Year:

1968

Language:

english

File:

PDF, 400 KB

english, 1968

29

Metabolic fate of cephacetrile after parenteral administration in rats and rabbits.

NAKAI, YOICHI, KANAI, YOSHIO, FUGONO, TAKESHI, TANAYAMA, SHIGEHARU

Journal:

The Journal of Antibiotics

Year:

1976

Language:

english

File:

PDF, 5.42 MB

english, 1976

30

Metabolic fate of SCE-963, a new broad-spectrum cephalosporin, after parenteral administration in rats and dogs.

TANAYAMA, SHIGEHARU, KONDO, TAKAO, KANAI, YOSHIO

Journal:

The Journal of Antibiotics

Year:

1978

Language:

english

File:

PDF, 4.28 MB

english, 1978

31

Bioactive Metabolites of EM574 and EM523, Erythromycin Derivatives Having Strong Gastrointestinal Motor Stimulating Activity.

FUNABASHI, YASUNORI, MAESHIBA, YOSHIHIRO, INATOMI, NOBUHIRO, TANAYAMA, SHIGEHARU, HARADA, SETSUO, ITOH, ZEN, OMURA, SATOSHI

Journal:

The Journal of Antibiotics

Year:

1996

Language:

english

File:

PDF, 612 KB

english, 1996

32

Determination of Small Amounts of Ketone Bodies in Blood.

Tanayama, Shigeharu, Ui, Michio

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1963

File:

PDF, 834 KB

1963

33

Brain distribution of idebenone (CV-2619) and its effect on local cerebral glucose utilization in rats.

NAGAI, Yasuo, YOSHIDA, Kiyoshi, NARUMI, Shigehiko, TANAYAMA, Shigeharu, NAGAOKA, Akinobu

Journal:

Folia Pharmacologica Japonica

Year:

1986

File:

PDF, 11.08 MB

1986

34

METABOLIC FATE OF 5-ETHOXYCARBONYL-3-MORPHOLINOSYDNONIMINE (SIN-10)

TANAYAMA, SHIGEHARU, FUJITA, TAKESHI, SHIRAKAWA, YOSHIHIRO, SUZUOKI, ZIRO

Journal:

The Japanese Journal of Pharmacology

Year:

1970

Language:

english

File:

PDF, 567 KB

english, 1970

35

STUDIES ON INCREASED BILE FORMATION PRODUCED BY POLYOXYBENZENES IN RATS

TANAYAMA, Shigeharu, KANAI, Yoshio

Journal:

The Japanese Journal of Pharmacology

Year:

1977

Language:

english

File:

PDF, 332 KB

english, 1977

36

STUDIES ON LANKACIDIN-GROUP (T-2636) ANTIBIOTICS

HARADA, SETSUO, TANAYAMA, SHIGEHARU, KISHI, TOYOKAZU

Journal:

The Journal of Antibiotics

Year:

1973

Language:

english

File:

PDF, 521 KB

english, 1973

37

Metabolic Fate of Ubiquinone-7

FUJITA, Takeshi, TANAYAMA, Shigeharu, SUZUOKI, Ziro

Journal:

Journal of Biochemistry

Year:

1971

Language:

english

File:

PDF, 487 KB

english, 1971

38

Disposition of ipriflavone (TC-80) in rats and dogs.

YOSHIDA, Kiyoshi, TSUKAMOTO, Takeji, TORII, Hiroshi, DOI, Takayoshi, NAESHIRO, Ichiro, SHIBATA, Kunihiko, UEMURA, Ieaki, TANAYAMA, Shigeharu

Journal:

Year:

1985

File:

PDF, 673 KB

1985